I consider Emsisoft the best and most safest AV to run. Emsisoft is generally the only AV I have put on my network that wasn't sufficiently hijacked to either use it to spy or to brick itself. I feel this is because Emsisoft is well designed, uses SSL for all communications and is hardened against most attacks. Also the distributed jurisdiction development of it is really good. Pretty tough to send national security letters or threaten a dispersed company! Emsisoft sends very little data out, which is another huge benefit.
Honestly? This may be hyperbole, but I think it's silly to run any other AV.. Forticlient is my other choice assuming you DO have a Fortigate Appliance AND Sandbox onsite. (which I do) If not, run Emsisoft and throw away those Norton and Trends.
I should put Emsisoft on my DMZ and see if they can either subvert it and use it to spy on me, or brick it like they've done to every other one. Gdata went down in flames a few days ago.
Then I can bug Umbra and Fabian about it.
My only recommendations for Emsisoft are they continue to examine hardening methods for their product and update system to avoid hijacking of it (if it's even possible right now). Also that they examine a more competitive pricing scheme. "Family" packages or unlimited licenses are a must these days, we all have like 10-20 devices or something and need better/larger packages for better pricing. For me to buy Emsisoft I would need 12 desktop/server/laptop licenses and 12 mobile device licenses. (tablets, phones, etc).. You can see how this gets really expensive unless a company offers unlimited device family licenses or bigger packages for cheaper. Or even look into a monthly subscription like most of the other AV's do now. I wouldn't even blink if I could get a multi-device license subscription for $5 a month or something.