Well, going to chip in my 2 cents:
Reliability: Kaspersky>ESET>Trend>Comodo
FP and issues: ESET>Trend=Kaspersky>Comodo
What you also need to look at it is issues that impact the system and FP.
No point having a nearly 80% built wall when there is cracks at the bottom (referring to issues and false positives). Prime example is Comodo: yes good defense but when something ain't working right, that wall will crumble.
Trend is middle of the pack. Not to say ESET doesn't have issues cause it does.
Best advice: to figure it out yourself, test them on a trial period each one on host machine versus your day to day operations.
Reason being: some will jump to ESET bandwagon, others to Kaspersky and the rest to Comodo (irony here is that only a few selected users I know that frequent the forum use Trend).
Take your pick and my 2 cents advice.