I don't know about this, but I am using a setup similar to CS' - HIPS and VirusScope disabled - with Andy Ful's WHHL and Configure Defender with no issues whatsoever. As
@bazang mentions above, it could be overkill, but keep in mind Andy's tools cause no additional impact on system resources. I run Windows 11, 23H2, using cfw v12.2.2.8012 latest stable. Only the firewall and Auto-Containment with "Restricted" containment level are enabled.
I wish the developers did a better job with the Firewall, as in its current form it's too modular and cumbersome to navigate comfortably around, although if you can wrap your head around it, it works well. I modified the built-in Web Browser Ruleset as such:
View attachment 284638
Anyway, I feel the developers put a lot of skill, ingenuity and effort into cfw. I would say go with the cruel setup and you will be fine. Btw, I had to weaken the Defender protection via Andy's tools before installing cfw, otherwise ASR, SRP and WDAC would interrupt.