My tips...
- if you have clean system you can first enable for some time "allow Microsoft app" level what gives you something like "leran/training mode"...than "ask user" is the best
- enable (settings) "run start of SS as service"
- make the list of user's protected files/folders what can protect your own documents/locations
- add vulnerable processes (browsers, media players, etc.) and location (mainly for downloaded or your temporary content) to restricted
- exclude security apps processes from keystroke encryption
- if you have firewall version check the list of parrents/children processes in "Aplication Execution Control" tab (Rules)...
- and perhaps many others that are the result of users own experience and needs