Not anything, but most of the unknowns.
Which configuration do you propose?
CIS/Xcitium does not contain the unknown DLLs loaded by applications (except for some LOLBins included in the Script Analysis panel).
However, the main problem is with Comodo's alerts. Most children should not be allowed to interact with containment alerts, because they tend to bypass the restrictions.
It is hard to configure CIS/Xcitium to be silent and very strong, without problems with software.
So yes, CIS/Xcitium can be really good for children, but not optimal for parents who must solve problems with silently blocked/contained software.
Post edited.