How about if I am not using windows defender ?When you are using your PC as Admin (not a seperate basic user account) and use Windows Defender as antivirus, simple use this profile and you are good to go. It is not a Default Deny (it has a hole in it, but uses the whitelist of WD to protect this hole). You probably end up using a full default deny policy, but this is a good first step in using a whitelist in stead of blacklist approach.
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Using Hard_Configurator in HARDENEDmode with ConfigureDefender in HIGHEST protection on Windows10 | Page 3 | MalwareTips
This for me would be a PITA. Your "Recommended" settings are more restrictive when using some W10 features from SUA, e.g Control Panel, but are simply...malwaretips.com