As spotted
by Leopeva64-2, Edge for Android has received a new experimental flag to improve how the browser blocks ads. With the new configuration, Edge for Android should block video ads better, such as YouTube prerolls. According to Leopeva64-2, the flag blocks video ads reasonably well, but your experience might be slightly different.
To test the updated ad blocker in Microsoft Edge on Android, download the browser from the Google Play Store and go to the
edge://flags/#edge-block-video-ads page. Set the flag to
Enabled and restart the browser. After that, try opening YouTube or any other website containing video ads.