I use Chrome and Edge. Some webs don't work fine with Chrome.
I think you'll be able to get used to it. The lack of on-hover and reload on change and whitelisting of google stuff might make you faster on NoScript but the addition of hpHosts, etc. on uMatrix and ScriptSafe makes you faster in deciding what to allow.I tried them didn't like there UI, fuctionality.
I will try these extensions againwhen next time i install chrome.uMatrix and ScriptSafe makes you faster in deciding what to allow.
Although, I don't allow js to run on any website except those which are safe and frequently visited by me. As what to allow i usually start with the main site then proceeds by seeing how it behaves. If it works without js, then i just don't allow it.