Comodo is mainly a whitelisting application. Signatures, VirusScope, Valkyrie, or any scanning (blacklisting) don't enhance its protection or usability. These scanning technologies only detect malicious elements in apps running in containment. So, you're already protected from malicious elements. If you're concerned about network connections from contained apps, it's better to set the firewall on alert or block mode rather than relying on scanners.
The user experience with Comodo will remain the same with Valkyrie, which is cloud protection that automatically determines if contained apps are malware. It won't automatically trust contained apps without human analysis.
Including a third-party antivirus database won't change the user experience with Comodo. Comodo doesn't run programs outside the containment based on signatures or scanners.
Comodo primarily relies on its safe lists. Signatures, VirusScope, and Valkyrie are secondary and don't improve usability. The issue for users is usability, not protection. Usability has improved greatly! Using cloud scanning protection is enough, and adding Valkyrie would be advantageous.