The registry cleaner in Wise Care 365 has minor issues with false positives, so should be used with caution. On the other hand the registry cleaner in Boost Speed (which is the same as their standalone registry cleaner) has zero issues with false positives, making it safe to use. Having said that, cleaning the registry is for the most part, pointless. While I have used it from time to time, I don't like Boost Speed much. But it is safe to use. The real time monitoring can cause slowdowns in some cases, but you can stop it from running in the background.
The tweaking and junk cleaning features in Wise Care are safe to use. But you get the same junk cleaner in Wise Disk Cleaner, and it has the benefit of not including a registry cleaner.
I did not sense a lot of improvement for registry cleaners, so I stopped using them.
For disk cleaners, I saw some savings for drive space, but also had problems with some browsers, so I decided to just rely on storage sense, and from there get more or larger drives.
For real-time optimization, I think the system no longer slowed down when apps misbehaved, but didn't speed up as much, and when more apps stopped misbehaving after they were updated, stopped using them as well.
For defragmenting issues, using an SSD is useful, but for some weird reason the system tends to be more snappy after I run the built-in app manually (e.g., trims the SSD and defrags all drives, and by default works only on small files), and it tends not to cope with some systems that are used for a lot of activity, e.g., play games, run apps, copy, more, or modify large numbers of small and large files across the same and various drives, install and uninstall apps, etc., so I'm trying various third-party programs, including those that don't defrag but instead do so on the fly.
For software updaters, I'm currently using Patch My PC, but for systems where there's a small SSD and some apps have to be installed in another drive, I can't use the automate option because by default some new software versions are installed in the boot drive.
Years ago I've used Regseeker to search and clean unneeded registry keys but it was very aggressive. I always reviewed it's results and allowed it to delete things that I thought were safe to delete.
Later I've used CCleaner's registry cleaner and it was much more conservative, finding much less data to delete. Still I checked it's results before deleting.
At the moment I don't use any registry cleaners as I don't see much benefit in doing so.
If you want to mess up your registry you could use JV16 Power Tools, originally RegCleaner around 20 years ago by two Finnish guys Jouni Vuorio and Jani Vuorio, now Macecraft which had an interesting past with crowdfunding There were many registries mess-ups up by the programs & often bug fixes contained removing many false positives, I don't know anyone who still uses it but it's still around - Not recommended !